Shuuichi Nitori is a boy who wants to be a girl and Yoshino Takatsuki is a girl who wants to be a boy. They meet in grammar school and learn one another's secrets. They become able to confide in each other as they grow up.
Yoshino and Saori have started their new lives in middle school. Things continue to be awkward as they go through their day to day. They join the various teams at the start of the semester; Yoshino to basketball and Saori to volleyball.
Having previously checked with Anna if it was okay to hang around Shuichi, Yoshino decides to wear a male uniform to school, much to the surprise of the other students and teachers.
Following the incident, Shuichi feels frustrated that they were treated differently from the times Chizuru and Yoshino came to school dressed opposite of their birth gender.
Once more, barbs and insults are exchanged when Yoshino and Saori meet. And despite animosity between Shuichi and Doi, Doi is asked to help write the script for the cultural festival play.